Technical Notes:

1. Highly reactive enantioselective catalyst for the asymmetric hyd rogenation of various substituted dehydroalanines to N-protected aminoacids. Also, catalyst is very effective in the asymmetric reduction of pentapetides that contain unsaturated Phe or Tyr linkages to enkephalin, a brain peptide hormone .

2.Efficient catalyst for the asymmetric reduction of enol acetates to esters.

3.Catalyst used to prepare chiral 2-substituted succinic acid derivatives.

References:

1.J.D. Morrison, Ed., Asymmetric Synthesis (Academic Press, New York, 1985), Vol. 5, 71.

2.Tetrahedron: Asymmetry, 1992. 3, 1247.

3.J.R. Kosak and T.A. Johnson, Eds., Chem Ind. (Marcel Dekker, Inc., New York, 1994) Vol. 53, 81.