CAS 200006-08-2; n-[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl]sarcosine hydrochloride; alx 5407 hydrochloride

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CAS:

200006-08-2

分子式:

C₂₄H₂₄NO₃F·HCl

分子量:

429.91

中文名称:

n-[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl]sarcosine hydrochloride

英文名称:

alx 5407 hydrochloride

nfps hydrochloride

alx-5407 hydrochloride

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

A919349

MACKLIN

N-[3-(4'-氟苯基)-3-(4'-苯基苯氧基)丙基]肌氨酸盐酸盐

≥98% (HPLC)

1320元/5mg; 5023元/25mg;

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储存：2-8°C,密封,干燥

SML0897

Sigma-Aldrich

ALX 5407 hydrochloride

≥98% (HPLC)

1330.03元/5 MG; 5077.25元/25 MG;

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产品说明

应用

ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

包装

5, 25 mg in glass bottle

生化/生理作用

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC₅₀ values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC₅₀ > 100 mM).

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₂₄H₂₄NO₃F·HCl
分子量	429.91
MDL编号	MFCD09971056
PubChem化学物质编号	329825613
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	Cl.CN(CC[C@@H](Oc1ccc(cc1)-c2ccccc2)c3ccc(F)cc3)CC(O)=O
InChI	1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1
InChI key	RPDGSZCYSJWQEE-GNAFDRTKSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H410
预防措施声明	P273 - P301 + P312 + P330
危险分类	Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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