CAS 51-55-8; 阿托品; atropine

CAS:

51-55-8

分子式:

C17H23NO3

分子量:

289.38

熔点:

114-118℃

中文名称:

阿托品

龙葵碱

颠茄碱

英文名称:

beta-phenyl-gamma-oxypropionsaure-tropyl-ester (german)

DL-Hyosyamine

troyl tropate

tropine, tropate (ester)

tropine tropate

tropic acid, ester with tropine

tropic acid, 3-alpha-tropanyl ester

tropic acid ester with tropine

isopto-atropine

eyesules

t-3-yl ester

endo-(+-)-alpha(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3,2,1]oc

dl-tropyltropate

dl-tropyl tropate

dl-tropanyl 2-hydroxy-1-phenylpropionate

dl-hyoscyamine

atropine

beta-phenyl-gamma-oxypropionsaeure-tropyl-ester

ester endo-(+-)-

benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3,2,1)oct-3-yl

ester endo-(+/-)-

benzeneacetic acid, alpha-(hydroxymethyl)- 8-methyl-8-azabicyclo[3.2.1]oct-3-yl

atropisol

atropinol

atropina

atropin-flexiolen

atropin

alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl

2-phenylhydracrylic acid 3-alpha-tropanyl ester

1alphah,5alphah-tropan-3alpha-ol (+-)-tropate (ester)

1-alpha-h,5-alpha-h-tropan-3-alpha-ol (+-)-tropate (ester)

(+,-)-tropyl tropate

性质描述:

该品为无色长柱状晶体。熔点为118-119℃。1g晶体能溶于455ml水、2ml醇、27ml甘油、25ml醚和1ml氯仿，也溶于苯。能与多种无机或有机酸生成水溶性盐。阿托品属莨菪烷型生物碱，即D，L-莨菪碱，存在于颠茄、曼陀萝等茄科植物中。

生产方法:

可从茄科东莨菪属植物唐古特山莨菪或喜马拉雅山莨菪的根中提取，也可以人工合成得到。

用途:

阿托品是副交感神经抑制剂，可作眼科的扩瞳剂、泻药；可缓减干草热、伤风鼻阻和肠痉挛；可用于治疗小儿夜尿症，有时用于舒减输尿管和胆道痉挛；还可用于治疗有机磷引起的中毒，作为抗胆碱药，阿托品的多方面药理作用，不利于其临床应用。现已陆续合成了一些具有专一作用的代用品，例如作为扩瞳剂的后马托品。阿托品毒性较大，剂量过大时可引起视觉模糊、分泌闭止、血管扩张、高热、兴奋、激动和谵妄。它是吗啡、毛果芸香碱、毒扁豆碱等的拮抗剂。