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CAS: 57-43-2
分子式: C11H18N2O3
分子量: 226.27
中文名称: 
异戊巴比妥
阿米妥
英文名称: 
somnal
ethylisopentylbarbituric acid
eunoctal
isoamylethylbarbituric acid
isomyl
isomytal
mylodorm
nsc 10815
pentymal
pentymalum
robarb
schiwanox
sednotic
dormytal
stadadorm
sumital
talamo
5-Ethyl-iso-amylbarbituric acid
5-Ethyl-5-iso-pentyl barbituric acid
5-Ethyl-5-(3-methylbutyl)2,4,6-(1H,3H,5H)-Pyrimidinetrione
isoamyl barbitone
5-ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
5-Ethyl-5-(3-methylbutyl)-barbitursαure
5-Ethyl-5-isopentyl barbituric acid
2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-(3-methylbutyl)-
amospan
6(1h,3h,5h)-pyrimidinetrione, 5-ethyl-5-(3-methylbutyl)-4
5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrione
5-ethyl-5-(3-methylbutyl)barbituric acid
5-ethyl-5-isoamylbarbituric acid
5-ethyl-5-isoamylmalonyl urea
5-ethyl-5-isopentylbarbituric acid
5-isoamyl-5-ethylbarbituric acid
amal
amasust
amital
amobarbital
amobarbitone
5-ethyl-5-isopentyl-barbituric aci
amybal
amylbarbitone
amylobarbital
amylobarbitone
amytal
barbamil
barbamyl
barbamyl acid
barbituric acid, 5-ethyl-5-isopentyl
binoctal
dorlotyn
性质描述: 该品为白色结晶性粉末。熔点为156-158℃。易溶于苯,溶于乙醚、氯仿、乙醚和碱溶液,微溶于水(每1300ml水溶1g),不溶于石油醚,饱和水溶液对石蕊呈酸性。无臭,略带苦味。
生产方法: 溴异戊烷经缩合、乙基化、环合而得。1.缩合将乙醇钠的乙醇溶液和乙酸乙酯加入干燥的反应罐中,65-70℃回流0.5h,冷至30℃以下,加入丙二酸二乙酯,搅拌1h。滴加溴异戊烷。加毕,45-50℃反应2h,升温至75-78℃,反应6h。回收乙醇至内温达120℃,再减压蒸除残留乙醇。冷至40℃时加水和少量磺化油,搅拌,静置分取酯层,减压蒸馏,收集相对密度为0.9622-0.9632馏分,得α-异戊基丙二酸二乙酯([5398-08-3],沸点240-242℃)。收率为84%。2.乙基化将乙醇钠的乙醇溶液和乙酸乙酯加入干燥的反应罐内,65-70℃回流0.5h,冷至40℃,加入异戊基丙二酸二乙酯,搅拌1h。于30℃加入溴乙烷。加毕,反应5h。升温至75-80℃,反应1h。蒸馏回收乙醇。冷至40℃,加水溶解。静置,分取酯层。减压蒸馏,收集相对密度为0.9532-0.9549馏分得α-乙基-α-异戊基丙二酸二乙酯。收率为87%。3.环合 由α-乙基-α-异戊基丙二酸二乙酯和尿素于75-80℃反应0.5h,回收乙醇,活性炭脱色,盐酸酸化,过滤,干燥得产品。环合收率为72-79%。
用途: 该品为中效类催眠药。具有镇静、催眠及抗惊厥作用。该品作用效果快而强。由于交易在肝内破坏,因此作用时间也短。久用会产生耐受性和成瘾性。肝肾功能严重不会时忌用或减量慎用。
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