| CAS: | 748810-28-8 | |
| 分子式: | C20H32ClNO4 | |
| 分子量: | 385.93 | |
| 中文名称: |
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| 英文名称: |
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| 用途: | Vernakalant hydrochloride 是一种混合电压和频率依赖性的 Na+ 和 K+ 通道阻断剂。Vernakalant 抑制 Kv1.5 channelwt，Kv1.5 channelI508F，Kv1.5 channelT479A，IC50 分别为 13.35±0.93 μM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||
| V877542 | MACKLIN | Vernakalant Hydrochloride | ≥99% | 622元/2mg; 1197元/5mg; 1873元/10mg; 3433元/25mg; 10729元/100mg; | 展开 | ||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||
| V795183 | MACKLIN | Vernakalant Hydrochloride | 10mM in DMSO | 1180元/1ml; | 展开 | ||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||
| SML2938 | Sigma-Aldrich | Vernakalant hydrochloride | ≥98% (HPLC) | 1042.98元/5 MG; 3365.56元/25 MG; | 展开 | ||||||||||||||||||||||||||||
产品说明 生化/生理作用 Vernakalant is a multiple ion channel blocker that exerts in vivo anti-fibrillatory (anti-arrhythmic) efficacy (ED50 = 1.5 μmol/kg/min iv. against ischemia-induced arrhythmias in rats) via atrial-selective Kv1.5 blockage (hKv1.5/rKv4.2/rKv4.3 IC50 = 13/38/30 μM at 1Hz & -80 to 60 mV in 200 (Kv1.5) or 400 (Kv4) msec) as well as potential- and rate-dependent Nav1.5 blockade (inward Na current INa IC50 = 9 μM/20 Hz & -80 mV, 31 μM/1Hz & -60 mV, 107 μM/1Hz & -120 mV using HEK hNav1.5 cells). 基本信息
产品性质
安全信息
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