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回肠绒毛刷状缘膜蛋白抗体
产品介绍 靶标: NAALADL1 产品别名: HILAP; I100; NAALADASEL; NAALADL1; N-acetylated alpha-linked acidic dipeptidase like 1; N-acetylated alpha-linked acidic dipeptidase like 1; aminopeptidase NAALADL1; 100 kDa ileum brush border membrane protein; N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L; human ileal aminopeptidase; ileal dipeptidylpeptidase; ileal peptidase I100; peptidase homolog; 回肠绒毛刷状缘膜蛋白; 背景信息: N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidyl-peptidase, is a Single-pass type II membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus, and ventral striatum. NAALADase L is a chloride-activated, membrane-bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders. 宿主:Rbt |
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