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TSPAN32抗体
产品介绍 靶标: TSPAN32 产品别名: ART1; PHEMX; PHMX; TSSC6; TSPAN32; tetraspanin 32; tetraspanin 32; tetraspanin-32; pan-hematopoietic expression protein; protein Phemx; tumor-suppressing STF cDNA 6; tumor-suppressing subchromosomal transferable fragment cDNA 6; tumor-suppressing subtransferable candidate 6; 背景信息: Phemx is a member of the tetraspanin (TM4SF) family of proteins that may be involved in transmembrane signal transduction, regulation of cell proliferation, differentiation and motility. Phemx is a multi-pass membrane protein containing intracellular N- and C-terminal domains, four transmembrane domains and two extracellular loops. It is ubiquitously expressed from early embryogenesis through adulthood. Phemx exhibits predominant expression in hematopoietic tissues suggesting a role in hematopoietic-cell function. In association with the Integrin ?IIb Integrin ??3 complex, Phemx functions to stabilize arterial thrombi in platelets and regulate ??outside-in??signaling. This interaction may be important in the process of wound healing. The gene encoding Phemx is located in an important tumor-suppressor gene region that has been associated with Beckwith-Wiedemann syndrome as well as a variety of cancers. 宿主:Rbt |
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