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APC2抗体
产品介绍 靶标: APC2 产品别名: APCL; MRT74; APC2; APC regulator of WNT signaling pathway 2; APC regulator of WNT signaling pathway 2; adenomatous polyposis coli protein 2; APC2, WNT signaling pathway regulator; adenomatosis polyposis coli 2; adenomatous polyposis coli like; 背景信息: APC2, which is also called APCL, is a deduced 2,303-amino acid protein that contains an N-terminal coiled-coil domain, followed by an armadillo domain and five 20-amino acid repeats. The human APC2 gene is mapped to chromosome 19p13.3. It is found that the 20-amino acid repeat domain of APCL could bind beta-catenin (CTNNB1) and deplete the intracellular beta-catenin pool. A reporter gene assay revealed that APCL could regulate interaction of beta-catenin with T cell-specific transcription factors (TCF7), although less efficiently than APC. 宿主:Rbt |
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