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核受体共激活因子NCOA62抗体
产品介绍 靶标: SNW1 产品别名: Bx42; FUN20; NCOA-62; PRPF45; Prp45; SKIIP; SKIP; SKIP1; SNW1; SNW domain containing 1; SNW domain containing 1; SNW domain-containing protein 1; SKI interacting protein; homolog of Drosophila BX42; nuclear protein SkiP; nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; ski-interacting protein; 核受体共激活因子NCOA62; 背景信息: This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. 宿主:Rbt |
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