产品介绍 靶标: METTL13 产品别名: 5630401D24Rik; CGI-01; DFNB26; DFNB26M; DFNM1; EEF1AKNMT; KIAA0859; feat; METTL13; methyltransferase 13, eEF1A lysine and N-terminal methyltransferase; methyltransferase 13, eEF1A lysine and N-terminal methyltransferase; eEF1A lysine and N-terminal methyltransferase; antiapoptotic protein FEAT; deafness (autosomal recessive, nonsyndromic) modifier 1; deafness (recessive, non-syndromic) modifier 1; deafness (recessive, nonsyndromic) modifier 1; eEF1A-KNMT; faint expression in normal tissues, aberrant overexpression in tumors; methyltransferase like 13; methyltransferase-like protein 13; KIAA0859蛋白; 背景信息: Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2 at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Has no activity towards core histones H2A, H2B, H3 and H4. Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6. 宿主:Rbt |
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