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E1A样分化抑制因子3抗体
产品介绍 靶标: Eid3 产品别名: 1700027M21Rik; NS4EB; Eid3; EP300 interacting inhibitor of differentiation 3; EP300 interacting inhibitor of differentiation 3; EP300-interacting inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; non-SMC element 4 homolog B; non-structural maintenance of chromosomes element 4 homolog B; E1A样分化抑制因子3; 背景信息: EID3?is highly expressed in testis and shows homology to a region of EID1 implicated in binding to CBP/p300. EID3 acts as a potent inhibitor of nuclear receptor transcriptional activity by a mechanism that is independent of direct interactions with nuclear receptors, including SHP. Furthermore, EID3 directly binds to and blocks the SRC-1 interacting domain of CBP, which has been implicated to act as the interaction surface for nuclear receptor co-activators. Consistent with this idea, EID3 prevents recruitment of CBP to a natural nuclear receptor-regulated promoter. 宿主:Rbt |
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