产品介绍 基因名： CARD16 产品别名： COP； COP1； LLID-114769； PSEUDO-ICE； CARD16； caspase recruitment domain family member 16； caspase recruitment domain family member 16； caspase recruitment domain-containing protein 16； CARD only domain-containing protein 1； CARD only protein； CARD-only protein 1； caspase recruitment domain-only protein 1； caspase-1 dominant-negative inhibitor pseudo-ICE； caspase-1 inhibitor COP； pseudo interleukin-1 beta converting enzyme； pseudo interleukin-1beta converting enzyme； pseudo-IL1B-converting enzyme； Caspase抑制剂COP蛋白； 背景信息： Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. 标签：His-tag |
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