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WDR5-0103

品牌
J&K
CAS
890190-22-4
货号
1578951
规格纯度
97%, 一个有效的含WD重复序列蛋白5 (WDR5) 选择性拮抗剂, Kd值为450 nM
参考价格
684 *本价格含增值税费
促销
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数量
-+
产品名称:
890190-22-4
WDR5-0103
WD-repeat protein 5-0103
产品介绍:

基本信息

分子式C21H25N3O4
分子量383.44
存储条件Freezer -20℃
产品描述 WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM. IC50 value: 450 nM (Kd) Target: WDR5 in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5. 靶点(IC50 & Targe) WDR5, 体外研究 体内研究 激酶实验 细胞实验 动物实验 参考文献 [1]. Senisterra G, et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J. 2013 Jan 1;449(1):151-159.

安全信息

图形或危害标志
危险说明H302
H410
防范说明P264
P270
P273
P301+P312
P330
P391
P501
UN号码3077
危险分类9
包装等级III

百灵威科技

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