4-氨基-N-(5,6-二甲氧基-4-嘧啶基)苯磺酰胺

产品名称：

2447-57-6
Sulfadoxine
周效磺胺
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
4-氨基-N-(5,6-二甲氧基-4-嘧啶基)苯磺酰胺

产品介绍：

基本信息

分子式	C₁₂H₁₄N₄O₄S
分子量	310.33
熔点	190-194
MDL编码	MFCD00792890
Beilstein	625453
Merck	14,8906
EINECS 编号	219-504-9
存储条件	Store at 2-8℃

一般描述

Chemical structure: sulfonamide

应用

Sulfadoxine is a sulfonamide antibiotic used in combination with pyrimethamine for the treatment or prevention of malaria. It is also used to treat various infections in livestock. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in patients where chloroquine resistance is suspected. It is used to study infections caused by Toxoplasma gondii and has been used to prevent infections after surgery during animal studies.

生化/生理作用

Sulfadoxine is a sulfonamide antibacterial that inhibits dihydropteroate synthase (DHPS), an enzyme that transforms 4-aminobenzoic acid (PABA) in the synthesis of dihydropteroic acid. This enzyme is also a component of the folate metabolic pathway and is upstream of dihydrofolate reductase (DHFR).

其他说明

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

安全信息

图形或危害标志
提示语	Warning
危险说明	H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	2
RTECS	DA9500000