基本信息
分子式 | C10H12ClNO2 |
分子量 | 213.66 |
MDL编码 | MFCD01321057 |
存储条件 | Freezer -20℃ |
产品描述
(R)-baclofen是一种γ-氨基丁酸衍生物,主要用于治疗痉挛。
靶点(IC50 & Targe)
GABAR
体外研究
Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.
参考文献
[1] Falch E, et al. J Neurochem, 1986, 47(3), 898-903.
[2] Penn RD, et al. Lancet, 1984, 1(8385), 1078.
安全信息
图形或危害标志 | |
提示语 | Warning |
危险说明 | H302 H410 |
防范说明 | P264 P270 P273 P301+P312 P330 P391 P501 |
UN号码 | 3077 |
危险分类 | 9 |
包装等级 | III |
WGK | 3 |
百灵威科技