(5Z,7E,22E)-9,10-开环麦角甾-5,7,10,22-四烯-1,3-二醇

产品名称：

54573-75-0
Doxercalciferol
度骨化醇
(5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
(5Z,7E,22E)-9,10-开环麦角甾-5,7,10,22-四烯-1,3-二醇

产品介绍：

基本信息

分子式	C₂₈H₄₄O₂
分子量	412.65
熔点	140
MDL编码	MFCD01076571
存储条件	Freezer -20℃

生化/生理作用

Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.Doxercalciferol is a vitamin D2 analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D2. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.

安全信息

图形或危害标志
提示语	Danger
危险说明	H300
防范说明	P501 P270 P264 P301+P310+P330 P405
UN号码	2811
危险分类	6.1
包装等级	I
RTECS	VS2950000