| CAS NO: | 11006-31-8 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 11006-31-8 |
| 别名 | Takacidin,U-0142 |
| 化学名 | 48-(7-amino-1-methylheptyl)-8,10,16,20,24,26,28,32,36,38,40,42,44,46-tetradecahydroxy-23-(α-D-mannopyranosyloxy)-9,15,17,19,21,25,31,33,39,41,47-undecamethyl-oxacyclooctatetraconta-13,17,21,29-tetraen-2-one |
| Canonical SMILES | OC(CC(C(C(C(O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)C(CO)O1)/C=C(C)/C(O)C(C)/C=C(C)/C(O)C(C)/C=C/CCC(O)C(C)C(O)CCCCCC2=O)O)C)O)/C=C/C(C)C(O)C(C)CCC(O)CC(O)C(C)C(O)C(C)C(O)CC(O)CC(O)C(C)C(O2)C(C)CCCCCCN |
| 分子式 | C72H133NO22 |
| 分子量 | 1364.8 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Monazomycin is a positively charged and polyenelike antibiotic produced by Streptomyces [1]. Monazomycin is able to induce a voltage-dependent conductance in lipid bilayer membranes. Monazomycin is selective for monovalent cations and can alter the membrane conductance when applied to one or both sides of the membrane [1]. Application of micromolar amounts of monazomycin on one side of phospholipid bilayer membranes induced dramatic voltage-dependent conductance effects. The steady-state conductance was proportional to the 5th power of the monazomycin concentration and increased exponentially with positive voltage (monazomycin side positive); there was an e-fold change in conductance per 4–6 mv. The major current-carrying ions were univalent cations. Monazomycin monomers cooperated to form a multimolecular conductance channel. The voltage control of conductance arose from the electric field driving monazomycin molecules at the membrane surface into the membrane and thus affecting the number of channels that were formed [2]. References: |
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