TopoisomeraseI inhibitor 3 (Compound ZML-14) is atopoisomeraseIinhibitor and can interact withtopoisomeraseI-DNA complex.TopoisomeraseI inhibitor 3 induces HepG2 cellapoptosisand arrests cell cycle at G2/M phase^[1].

Topoisomerase I inhibitor 3 (Compound ZML-14) shows cytotoxicity with IC₅₀values of 1.94 ± 0.09, 10.32 ± 0.39, 13.1 ± 0.96, 40.69 ± 5.36, 28.11 ± 2.50, >100 and 37.42 ± 2.05 μM against HepG2, A2780, HeLa, HCT116, SW1990, MCF7 and L-02 cells, respectively^[1].

311.31

C₁₈H₁₄FNO₃

2588211-50-9

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