CAS NO: | 191089-59-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | K-7174 is an orally activeproteasomeandGATAinhibitor. K-7174 is acell adhesioninhibitor. K-7174 induces cellapoptosis. K-7174 shows antitumor activities, it can be used for the research ofcancer[1][2][3]. | ||||||||||||||||||||||||
体外研究 (In Vitro) | K-7174 (10 μM; 1 h) inhibits the adhesion by VCAM-1 and its ligand[1].K-7174 (1-30 μM; 1 h) dose-dependently suppresses the VCAM-1 expression with an IC50value of 14 μM[1].K-7174 (1-30 μM; 1 h) dose-dependently suppresses the induction of VCAM-1 mRNA by TNFα with an IC50value of 9 μM[1].K-7174 (10-20 μM; 24 h) dose-dependently rescues Epo production by Hep3B cells[2].K-7174 (2.5-30 μM; 24 h) inhibits the binding activity of GATA[2].K-7174 (0-25 μM; 72 h) inhibits MM cells growth and induces cell apoptosis[3]. Cell Viability Assay[3]
Apoptosis Analysis[3]
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体内研究 (In Vivo) | K-7174 (30 mg/kg; i.p. once daily for 9 days) reverses the decreasing of hemoglobin concentrations and reticulocyte counts by IL-1β or TNF-α[2].K-7174 (75 mg/kg; i.p. once daily for 14 days) inhibits the tumor growth in vivo[3].K-7174 (50 mg/kg; p.o. once daily for 14 days) inhibits the tumor growth in vivo and shows a better effect than intraperitoneal injection[3].
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分子量 | 568.74 | ||||||||||||||||||||||||
Formula | C33H48N2O6 | ||||||||||||||||||||||||
CAS 号 | 191089-59-5 | ||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |