Bavachalcone is a major bioactive compounds isolated fromPsoralea corylifoliaL.; has been widely used as traditional Chinese medicine;antibioticor anticancer agent. IC50 value: Target: Bavachalcone inhibited osteoclast formation from precursor cells with the IC(50) of approximately 1.5 microg ml(-1). The activation ofMEK,ERK, andAktby receptor activator of nuclear factor kappaB ligand (RANKL), the osteoclast differentiation factor, was prominently reduced in the presence of bavachalcone. The induction of c-Fos and NFATc1, key transcription factors for osteoclastogenesis, byRANKLwas also suppressed by bavachalcone [1]. Bavachalcone exhibited a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro [2]. Bavachalcone had stronger inhibition on UGT1A1 and UGT1A7 than corylin which did not inhibit UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A10, and UGT2B4. Data fitting using Dixon and Lineweaver-Burk plots demonstrated the noncompetitive inhibition of bavachalcone against UGT1A1 and UGT1A7-mediated 4-MU glucuronidation reaction. The values of inhibition kinetic parameters (Ki) were 5.41 μ M and 4.51μ M for UGT1A1 and UGT1A7, respectively [3].

324.37

Solid

C₂₀H₂₀O₄

28448-85-3

• Flavonoids
• Chalcones

• Phenols
• Polyphenols

• Plants
• Leguminosae
• Psoralea corylifoliaL.

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 34 mg/mL(104.82 mM)

*"≥" means soluble, but saturation unknown.

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