Kusunokinin

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Kusunokinin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

58311-20-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

(-)-Kusunokinin

产品介绍

Kusunokinin ((-)-Kusunokinin) 是一种天然产物，可以从P. nigrum中分离出来。Kusunokinin 具有抗癌活性。Kusunokinin 可将细胞周期阻滞在 G2/M 期并诱导细胞凋亡 (apoptosis)。

生物活性

Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated formP. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induceapoptosis^[1].

体外研究
(In Vitro)

Kusunokinin ((-)-Kusunokinin; 0.625-10 μg/mL; 72 h) 抑制癌细胞的活力，对 MCF-7、HT-29、MDA-MB-468、SW-620、A-549 和 MDA-MB-231 细胞的 IC₅₀值分别为 3.08、3.59、3.98、5.75、5.77 和 7.86 μM^[1]。

Cell Viability Assay^[1]

Cell Line:	Cancer cells
Concentration:	0.625, 1.25, 2.5, 5 and 10 μg/mL
Incubation Time:	72 hours
Result:	Had anticancer activity and inhibited cancer cells growth.

体内研究
(In Vivo)

Kusunokinin ((-)-Kusunokinin; 7 和 14 mg/kg; i.h.; 每周 3 次, 持续 2 周) 通过下调信号分子 (c-Src、PI3K、Akt 和 Erk1/2) 抑制 NMU 诱导的乳腺癌大鼠的肿瘤生长^[1]。

Animal Model:	Female Sprague Dawley rats (7 weeks of age)^[1]
Dosage:	7 and 14 mg/kg
Administration:	Subcutaneous injection, 3 times a week for 2 weeks
Result:	Inhibited the mammary tumor growth and decreased tumor volume. Down-regulated c-Src, Erk1/2 and PI3K proteins and decreased Akt proteins. Inhibited downstream molecules in the cell cycle (c-Myc, E2f-1, CDK1 and cyclin B1) and metastasis (E-cadherin, MMP-2 and MMP-9).

分子量

370.40

Formula

C₂₁H₂₂O₆

CAS 号

58311-20-9

结构分类

Phenylpropanoids
Lignans

来源

Plants
Piperaceae
Piper nigrumLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.