SKF 100398

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SKF 100398

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	77453-01-1
包装:	1mg
市场价:	8500元

产品名称

d(CH2)5Tyr(Et)VAVP

产品介绍

SKF 100398 (d(CH2)5Tyr(Et)VAVP) 是一种精氨酸加压素 (AVP) 类似物，能作为外源性和内源性AVP抗利尿作用的特异性拮抗剂。

生物活性

SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenousAVP^[1].

体内研究
(In Vivo)

SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP^[1].
SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP^[1].

Animal Model:	Male Sprague-Dawley rats (250-300 g)^[1]
Dosage:	8 μg/kg
Administration:	Intravenous injection
Result:	Completely blocked the antidiuretic effect of exogenous AVP (4 ng/kg body wt i.v.).

分子量

1136.39

性状

Solid

Formula

C₅₃H₇₇N₁₃O₁₁S₂

CAS 号

77453-01-1

Sequence

{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: 1-Cys6)

Sequence Shortening

{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-YFVNCPRG-NH2 (Disulfide bridge: 1-Cys6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)