Autotaxin-IN-1

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Autotaxin-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1619971-30-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Autotaxin-IN-1 是一种有效的自分泌运动因子(autotaxin)抑制剂，具有良好的效力 (IC₅₀=2.2 nM)，PK 特性和良好的 PK/PD 关系。Autotaxin-IN-1 可用于骨关节炎疼痛的研究。

生物活性

Autotaxin-IN-1 is a potentautotaxininhibitor, which has favorable potency (IC₅₀=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain^[1].

IC₅₀& Target^[1]

Autotaxin

2 nM (IC₅₀)

体内研究
(In Vivo)

Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T_1/2of 1.14 hours^[1].
Autotaxin-IN-1 (p.o.; 10 mg/kg) has C_maxof 660 nM and AUC of 3440 nMoh^[1].

Animal Model:	Normal rat^[1]
Dosage:	1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study)
Administration:	I.v. (1.0 mg/kg); p.o. (10 mg/kg)
Result:	Has T_1/2of 1.14 hours (i.v.; 1.0mg/kg). Has C_maxof 660 nM and AUC of 3440 nM?h (p.o.; 10 mg/kg).

分子量

405.45

Formula

C₂₁H₂₃N₇O₂

CAS 号

1619971-30-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.