Levalbuterol hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

50293-90-8

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

(R)-Albuterol hydrochloride
(R)-Salbutamol hydrochloride
Levosalbutamol hydrochloride

产品介绍

Levalbuterol ((R)-Albuterol) hydrochloride 是短效 β2-肾上腺素受体 (β2-adrenergic receptor) 激动剂和 Salbutamol 的活性 R 型对映异构体。Levalbuterol hydrochloride 是一种比 Salbutamol 更有效的支气管扩张试剂，可用于哮喘和慢性阻塞性肺疾病 (COPD) 的研究。

生物活性

Levalbuterol ((R)-Albuterol) hydrochloride is a short-actingβ2-adrenergic receptoragonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD^[1].

体外研究
(In Vitro)

Levalbuterol (10 μM; 24 hours) hydrochloride induces11β-HSD1mRNA expression, however, it does not influence11β-HSD2expression in airway epithelial cells^[1].
Levalbuterol (10 μM; 24 hours) hydrochloride significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line^[1].

RT-PCR^[1]

Cell Line:	Murine Club (MTCC) cells
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Increased11β-HSD1mRNA expression selectively.

体内研究
(In Vivo)

Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) hydrochloride significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE^[2].

Animal Model:	C57BL/6 female mice with a pulmonary allergic model^[2]
Dosage:	1 mg/kg
Administration:	Subcutaneous injection; 1 mg/kg; 14 days
Result:	Decreased pulmonary inflammation after OVA sensitization.

分子量

275.77

性状

Solid

Formula

C₁₃H₂₂ClNO₃

CAS 号

50293-90-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 100 mg/mL(362.62 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.6262 mL	18.1311 mL	36.2621 mL
5 mM	0.7252 mL	3.6262 mL	7.2524 mL
10 mM	0.3626 mL	1.8131 mL	3.6262 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (362.62 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。