PDE9-IN-1

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PDE9-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2305087-92-5

包装与价格：

产品介绍

PDE9-IN-1 是一种有效选择性的、可口服生物利用的磷酸二酯酶-9(PDE9)抑制剂，IC₅₀值为 8.7 nM。

生物活性

PDE9-IN-1 is a potent, selective, and orally bioavailablephosphodiesterase-9A (PDE9A)Inhibitor with anIC₅₀of 8.7 nM^[1].

IC₅₀& Target^[1]

PDE9A

8.7 nM (IC₅₀)

体外研究
(In Vitro)

PDE9-IN-1 is excellent selectivity across PDE families^[1].

体内研究
(In Vivo)

PDE9-IN-1 (2.5 and 5.0 mg/kg; Oral administration; daily for 21 days) effectively recovers learning and memory function^[1].

Animal Model:	Unilateral common carotid artery occlusion (UCCAO) mouse model^[1]
Dosage:	2.5 and 5.0 mg/kg
Administration:	Oral administration; daily for 21 days
Result:	Significantly reduced the day 6 escape latency time and increased the frequency of platform area crossings, and recovered learning and memory function. High dose group possibly improved the escape latency time of mice.

分子量

362.40

Formula

C₁₇H₂₃FN₆O₂

CAS 号

2305087-92-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.