Irsenontrine (E2027) maleate is an orally active and selectivephosphodiesterase9 (PDE9) inhibitor. Irsenontrine maleate can be used for the research of neurological diseases^[1][2].

PDE9^[1]

Irsenontrine (0.3, 3.3 mg/kg; p.o.) maleate exhibits a significant ameliorative effect on the percentage of exploration of the novel object at 3.3 mg/kg in Scopolamine-induced rats^[1].
Irsenontrine (1 mg/kg; p.o.) maleate and memantine hydrochloride (1 mg/kg; p.o.) combined treatment group exhibits a significantly higher percentage of exploration of the novel object than memantine hydrochloride (1 mg/kg) alone^[1].

506.51

C₂₆H₂₆N₄O₇

1630083-70-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.