Cav 3,2 inhibitor 3

立即咨询

Cav 3,2 inhibitor 3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Cav 3.2 inhibitor 3 (Compound 4) 是一种有效的Ca_v3.2 T-type Ca²⁺channel抑制剂，IC₅₀为 0.1534 μM，对 D₂受体的结合亲和力很小。

生物活性

Cav 3.2 inhibitor 3 (Compound 4) is a potentCa_v3.2 T-type Ca²⁺channelinhibitor with anIC₅₀of 0.1534 μM, and has little binding affinity to D₂receptors^[1].

IC₅₀& Target^[1]

Ca_v3.2

0.1534 μM (IC₅₀)

体内研究
(In Vivo)

Cav 3.2 inhibitor 3 (Compound 4) (1-10 mg/kg; i.p.; once) potently suppresses T-channel-dependent somatic and visceral pain in mice^[1].

Animal Model:	C57BL/6J mice, Ca_v3.2-dependent somatic and visceral pain model^[1]
Dosage:	1, 3 and 10 mg/kg
Administration:	Intraperitoneal administration, once
Result:	Reduced the mechanical allodynia in the hindpaw and colonic pain/referred hyperalgesia following i.pl. and i.col. administrations of Na₂S, a donor of H₂S, respectively. Suppressed the i.pl. Na₂S-induced paw allodynia in a dose-dependent manner, and the maximally effective doses were roughly estimated at 10 mg/kg.

分子量

495.66

Formula

C₃₂H₃₇N₃O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.