PBIT 是一种特异性 Jumonji/AT 富集互作结构域 1 抑制剂，抑制JARID1A和JARID1C，IC50分别为 6 和 4.9 μM。它抑制JARID1B(KDM5B或PLU1) 组蛋白去甲基化酶，IC50值约为 3 μM。

PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes .

PBIT, which inhibits JARID1B with an IC50 of about 3 μm in vitro.?Consistent with this, PBIT treatment inhibited removal of H3K4me3 by JARID1B in cells.?Furthermore, this compound inhibited proliferation of cells expressing higher levels of JARID1B.

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DMSO:100 mg/mL (414.40 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years