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TBK1 PROTAC® 3i
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TBK1 PROTAC® 3i图片
CAS NO:2052306-13-3
包装:5mg
市场价:5366元

产品介绍
Cas No.2052306-13-3
Canonical SMILESCN(C(C1CCC1)=O)CCCNC2=NC(NC3=CC=C(C=C3)OCCCOCCCCOCCCOCC(N[C@@H](C(C)(C)C)C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)O)=O)=O)=NC=C2Br
分子式C53H74BrN9O9S
分子量1093.19
溶解度DMSO|109.32|100|
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent TANK-binding kinase 1 (TBK1) Degrader (DC50 = 12 nM, Dmax = 96%). Exhibits >50-fold selectivity for TBK1 over the closely related IKKε. Comprises a ligand for von-Hippel Lindau (VHL) protein joined by a linker to a TBK1-targeting moiety. Brings about near complete degradation of TBK1 in mutant K-Ras and wild-type cancer cell lines with no significant effect of proliferation. Negative control TBK1 control PROTAC(R) 4 also available.