| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Canonical SMILES | NC(C=CN1[C@H]2C(F)([C@@H]([C@H](O2)CO[Si](C(C)C)(OCCCCCN3C(C=CC3=O)=O)C(C)C)O)F)=NC1=O |
| 分子式 | C24H36F2N4O7Si |
| 分子量 | 558.65 |
| 溶解度 | DMSO: 100 mg/mL (179.00 mM); Water:< 0.1 mg/mL (insoluble) |
| 储存条件 | 4℃, stored under nitroge |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent;), linked via the ADC linker[1]. Antibody drug conjugates (ADC) couple therapeutic monoclonal antibodies (mAb) with potent toxins through a linker that is stable within systemic circulation, but cleaves within the target cells[1]. [1]. Mathew C. Finniss, et al. A versatile acid-labile linker for antibody-drug conjugate. MedChemComm, Issue 9, 2014. |
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