A1874 是一种基于 n??utlin 的 BRD4 降解 PROTAC，可诱导细胞中的 BRD4 降解，DC50值为 32 nM。它有效抑制许多癌细胞系的增殖。

A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.

2064292-12-0

C58H62Cl3F2N9O7S

1173.6

DMSO:150 mg/mL (127.81 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years