TD-165 是一种基于 PROTAC 技术的CRBN降解剂。它包括一个 CRBN 配体结合基团，一个 linker 和一个 VHL 结合基团。

TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group[1].

Administration of 0.1-10?μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells[1]. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4?nM and a maximum degradation (Dmax) value of 99.6%[1].

2305936-56-3

C46H59N7O8S

870.07

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