5-Aminouridine 修饰核碱基并掺入靶 DNA。 5-Aminouridine 抑制肿瘤、病毒和真菌的生长。

5-Aminouridine modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.

5-Aminouridine inhibits the incorporation of carbamyl aspartate into pyrimidines of both RNA and DNA in rat lived and [32P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma[1]. 5-Aminouridine must exhibit a low potential to be oxidized by Os(bpy)33+. The modified nucleobase is inserted into the target DNA by direct synthesis using modified phosphoramidites[4].

5-Aminouridine inhibits the incorporation of carbamoylaspartate into pyrimidines in living rat RNA and DNA, and the incorporation of [32P]phosphate into phospholipids and RNA nucleotides in rat liver slices and liver cancers [1].

2149-76-0

C9H13N3O6

259.22

4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years