FGI-106 tetrahydrochloride 对多种病毒具有抑制活性，有抗埃博拉病毒，裂谷病毒和登革热病毒的EC50分别为 100 nM，800 nM 和 400-900 nM，抑制非失血性发热病毒HCV和HIV-1的EC50分别为 200 nM 和 150 nM 。

FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively. FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses.

In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM.

FGI-106??treatment decreases mortality from Zaire EBOV in a dose-dependent manner.

1149348-10-6

C28H42Cl4N6

604.49

DMSO:7.5 mg/ml (12.41 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years