| CAS NO: | 102636-74-8 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 102636-74-8 |
| Canonical SMILES | O=C(CN(CC)CC)N1C(C=C(NC(OCC)=O)C=C2)=C2CCC3=C1C=CC=C3 |
| 分子式 | C23H29N3O3 |
| 分子量 | 395.5 |
| 溶解度 | DMSO: 100 mM,Ethanol: 100 mM |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CINPA1 is a constitutive androstane receptor (CAR) antagonist (IC50 = 70 nM in a reporter assay).1 It is selective for CAR over the nuclear receptors GR, FXR, LXRα, LXRβ, PPARγ, RXRα, and RXRβ at 18 μM, but also antagonizes the human pregnane X receptor (PXR; IC50 = 6.6 μM). CINPA1 (0.3-5 μM) inhibits CAR transactivation of CYP2B6 induced by CITCO in primary human hepatocytes. |1. Cherian, M.T., Lin, W., Wu, J., et al. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol. Pharmacol. 87(5), 878-889 (2015). |
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