Fucosterol 是从藻类、海藻或硅藻中分离的一种甾醇，具有抗氧化、抗脂肪、降低血液胆固醇、抗糖尿病和抗癌活性。它通过抑制PPARα和C/EBPα的表达调控脂肪生成，可用于抗肥胖试剂开发研究。

Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.

Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes [1]. Fucosterol shows cytotoxicity against T47D and HT29 cell lines (IC50s: 27.94 and 70.41 μg/ml) [3]. Fucosterol decreases the proliferation of HEK293, MCF-7, and SiHa cells (IC50s: 185.4, 43.3, and 34.0 μg/ml) [4].

Fucosterol (p.o.; 30mg/kg) causes a significant decrease in serum glucose concentrations and exhibits inhibition of sorbitol accumulations in the lenses [2].

Cell Line: 3T3-L1 adipocytes. Concentration: 0 μM; 25 μM; 50 μM. Incubation Time: 7 days [1]

17605-67-3

C29H48O

412.702

岩藻甾醇;岩皂甾醇

Ethanol:16.67 mg/mL (4.39 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years