Anemarsaponin B 是一种甾体皂苷，可降低iNOS和COX-2的蛋白和 mRNA 水平，减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-Κb的 p65 亚基的核转位，还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。

Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B can inhibit PAF-induced rabbit platelet aggregation in vitro.

139051-27-7

C45H74O18

903.06

知母皂苷B;知母皂苷 B

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years