Withanolide A 提取于印度草药 Ashwagandha 中，在严重受损的神经元中，能再生神经元突并重建突触。它延长了人类 EGFR 驱动的癌性秀丽隐杆线虫的寿命。

Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

A quantitative structure activity relationship (QSAR) model was developed by a forward stepwise multiple linear regression method to predict the activity of Withanolide Analogs against human breast cancer. The most effective QSAR model for anticancer activity against the SK-Br-3 cell showed the best correlation with activity (r2=0.93 and rCV2 =0.90). Similarly, cross-validation regression coefficient (rCV2=0.85) of the best QSAR model against the MCF7/BUS cells showed a high correlation (r2=0.91). In particular, compounds CID 73621, CID 435144, CID 301751 and CID 3372729 have a marked antiproliferative activity against the MCF7/BUS cells, while 2,3-dihydrowithaferin A-3-beta-O-sulfate, withanolide 5, Withanolide A, withaferin A, CID 10413139, CID 11294368, CID 53477765, CID 135887, CID 301751 and CID 3372729 have a high activity against the Sk-Br-3 cells compared to standard drugs 5-fluorouracil (5-FU) and camptothecin[1]

32911-62-9

C28H38O6

470.6

DMSO:55 mg/ml (116.87 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years