Eberconazole nitrate 是一种二氯咪唑衍生物，具有抗真菌活性，效果比Ketoconazole、Clotrimazole和Miconazole强。它通过局部给药对皮肤癣菌病具有潜在的研究价值。

Eberconazole Nitrate is an azole antifungal agent and broad-spectrum imidazole derivative.

Spherical and porous Eberconazole Nitrate(EB) microsponge particles were obtained.?The optimized microsponges possessed particle size, drug content and entrapment efficiency of 24.5 μm, 43.31% and 91.44%, respectively.?Microsponge-loaded gels demonstrated controlled release, nonirritancy to rat skin and antifungal activity.?An in vivo skin deposition study demonstrated fourfold higher retention in the stratum corneum layer as compared with commercial cream[1].

Eberconazole Nitrate(EB) microsponges were prepared using the quasiemulsion solvent diffusion method.?The effect of formulation variables (drug:polymer ratio, internal phase volume and amount of emulsifier) and process variables (stirring time and stirring speed) on the physical characteristics of microsponges were investigated.?The optimized microsponges were dispersed into a hydrogel and evaluated[1].

130104-32-4

C18H15Cl2N3O3

392.24

硝酸依柏康唑;Ebernet

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years