LCB 03-0110 Dihydrochloride是BTK和Syk家族以及DDR2家族中c-Src激酶（IC50=1.3 nM）和酪氨酸激酶的有效抑制剂。在体外抑制LPS诱导的巨噬细胞活化和TGF-β1诱导的成纤维细胞活化，抑制巨噬细胞和成纤维细胞的活化，并抑制伤口愈合模型中的瘢痕形成。

LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-β1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models.

LCB 03-0110 treatment of cells exposed to TGF-β1 and type I collagen showed a marked inhibition preferentially in the phosphorylation of tyrosine 861, to give approximately 50% reduction at 1 μM and an almost complete abolishment at 3 μM.

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years