PI3K/mTOR Inhibitor-2 是一种有效的 PI3K 和 mTOR 泛抑制剂，对 PI3Kα、PI3Kβ、PI3Kδ、PI3Kγ 和 mTOR 的 IC50 分别为 3.4、34、16,1 和 4.7 nM。 PI3K/mTOR Inhibitor-2 具有抗肿瘤活性。

PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity.

PI3K/mTOR Inhibitor-2 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation with IC50s of 11.6 and 89.2 nM in cell assays, and good pharmacokinetic profile[1].

PI3K/mTOR Inhibitor-2 demonstrated in vivo efficacy in a PC-3M tumor xenograft model[1].

1848242-58-9

C20H13ClF2N4O4S

478.86

DMSO:8.33 mg/mL (17.40 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years