C-021 dihydrochloride 是一种有效的 CCR4 拮抗剂。 它有效抑制人和小鼠的功能趋化性，IC50 为 140 nM 和 39 nM。

C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.

C-021 (Compound 1b) effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM). In human liver microsomes (HML), C-021 exhibits CLint value of 17,377 mL/h/kg[1].

In the murine oxazolone-induced contact hypersensitivity test, the potency of C-021 is evident after subcutaneous administration. When C-021 is administered orally, however, very little inhibition is observed[1]. C-021 (1 mg/kg; i.p.; daily; for 3 days) significantly less microgliosis in acute liver failuremice[2]

1784252-84-1

C27H43Cl2N5O2

540.57

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years