2-hydroxychalcone 是一种天然黄酮,可通过下调 BCL-2 诱导凋亡,也可抑制NF-kB 的激活。它是抗氧化剂,抑制脂质过氧化,还可抑制三阴性乳腺癌细胞的侵袭。
产品描述
2-Hydroxychalcone can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells.
体外活性
2-hydroxychalcone induced apoptosis by Bcl-2 downregulation.?2-hydroxychalcone and xanthohumol exerted more potent inhibitory effects on the proliferation, MMP-9 expression and invasive phenotype of MDA-MB-231 than chalcone[1].
Cas No.
644-78-0
分子式
C15H12O2
分子量
224.259
别名
2-(2-Hydroxybenzal)Acetophenone;2-羟基查酮
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years