Talampanel 是一种口服和选择型AMPA受体拮抗剂，具有抗癫痫活性。在啮齿动物的中风模型中，它 具有神经保护作用。Talampanel 减弱 Caspase-3 依赖性细胞凋亡。

Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.

Talampanel (p.o.; 5 mg/kg; once a day; 2 weeks) decreases motoneuronal calcium in a mouse model of ALS [1].

161832-65-1

C19H19N3O3

337.37

LY-300164;GYKI-53773

DMSO:100 mg/mL (296.41 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years