JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).

Compared with WT, JNJ‐4628122 binds to the selected mGlu2?receptor mutants is significantly decreased by approximately 10‐fold. Mutations F643A and N735D are selected, in transfected mGlu2?WT and mutant receptors in CHO‐K1 cells [1].

1254980-38-5

C23H25F3N4

414.47

DMSO:62.5 mg/mL (150.79 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years