LXR antagonist 2 (compound 10rr) 是一种有效的LXR(肝 X 受体)反向激动剂。其对 LXRβ 和 LXRα 的IC50值分别为 0.36 和 2.25 μM。 LXR antagonist 2 是脂肪生成抑制剂，通过下调LXR靶基因 SREBP-1c、ACC、FAS和 SCD-1 而作用。LXR antagonist 2 对 Triton WR-1339 诱导的高脂血症小鼠有降脂作用。

LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, with IC 50 values of 0.36 and 2.25 μM for LXRβ and LXRα, respectively. LXR antagonist 2 is a lipogenesis inhibitor through down-regulating LXR target genes SREBP-1c, ACC, FAS and SCD-1. LXR antagonist 2 shows lipid-lowering effects in mice with Triton WR-1339-induced hyperlipidemia [1].

C34H40N2O5S

588.76

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years