Hexa-D-arginine 是稳定的furin抑制剂，能够作用于 furin (Ki:106 nM)、PACE4 (Ki:580 nM)、PC1 (Ki:13.2 nM)。它在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。

Hexa-D-arginine is an inhibitor of furin,blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.

The small stable furin inhibitor hexa-D-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic.?Administration of hexa-D-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha[1].

673202-67-0

C36H75N25O6

954.165

H2O:50mg/L (52.40mM)
DMSO:20.96mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years