ErSO 是一种通过 ERα 受体的，预期未折叠蛋白反应 (UPR) 的特异性激活剂。 ErSO 可用于抗癌研究。

ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.

In MCF-7 cells, ErSO (1-1000 nM) inhibits cell viability with an IC50 of 20.3 nM. ErSO (1 μM) rapidly kills ERα-positive breast cancer cells in TYS and TDG cells and induces rapid killing of ERα-positive MCF-7 human breast cancer cells[1].

ErSO (10 and 40 mg/kg; p.o.) induces >100000-fold regression (to undetectable amounts) within 14 days and >10000-fold regression of TYS-luciferase-expressing breast tumors in all five mice. In Nu/J mice, ErSO (10 or 40 mg/kg; p.o.) eliminates tumors with >90% reduction in all cases[1].

2407860-35-7

C22H13F6NO3

453.33

ErSO

DMSO:100 mg/mL (220.6 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years