IMP-1710 is an inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1; IC50= 38 nM in a fluorescence polarization assay) that contains an alkyne moiety for use in click chemistry reactions.1It is selective for UCH-L1 over a panel of 20 deubiquitinating enzymes at 1 μM. IMP-1710 inhibits TGF-β1-induced fibroblast-to-myofibroblast transition (FMT) in primary lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis (IC50= 740 nM). It has been used for labeling UCH-L1 in cell-based assays, followed by click reactions with azide-modified TAMRA and biotin capture reagents.

2383117-96-0

C23H19N5O

381.439

IMP-1710

Chloroform:10 mg/mL
Ethanol:5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years