SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668.

In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively.

2117405-48-6

C24H20F3N3O4S

503.49

SW203668 (trifluoroacetate salt)

DMSO:20 mg/mL
DMF:20 mg/mL
Ethanol:20 mg/mL
Ethanol:PBS (pH 7.2) (1:3):0.25 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years